Lake Keowee is a prime destination for boaters, anglers, and outdoor enthusiasts looking to experience one of South Carolina’s most scenic lakes. Whether you’re planning a family vacation, a weekend escape, or a group retreat, finding the right rental can make all the difference. These top vacation rentals offer lakefront access, private docks, and amenities like hot tubs, game rooms, and spacious decks for enjoying the view. From luxurious estates to cozy waterfront retreats, each property provides a great base for exploring Lake Keowee’s 300 miles of shoreline, waterfalls, and hidden coves. If you’re looking for a place to stay with easy water access and plenty of ways to relax, these Lake Keowee vacation rentals are worth considering. Please note: Clicking on the links will direct you to VRBO, and we may earn a commission if you book through these links.

• Bedrooms: 10
• Bathrooms: 10
• Sleeps: 22
• Average Price per Night: $2,047

This stunning 10-bedroom estate on Lake Keowee is the ultimate getaway for large groups, offering space, luxury, and unbeatable lake access. With a private pool, covered dock, and poolside fireplace, this home is built for both relaxation and entertainment. The open-concept main level is perfect for gathering, while multiple living spaces across three floors ensure everyone has room to unwind. Step outside to soak in lake views from the spacious decks, or take a short boat ride to the Tiki Hut and Lake Keowee Marina. Located just 10 minutes from downtown Seneca’s restaurants and breweries, and 20 minutes from Clemson and Death Valley, this home is perfect for family reunions, game day weekends, or lake lovers looking for an upscale retreat. Plus, with Lake Jocassee just a short drive away, even more adventure awaits. If you’re planning a lakeside event, this property is hard to beat!

• Bedrooms: 5
• Bathrooms: 5 Full & 2 Half
• Sleeps: 15
• Average Price per Night: $1,787

Tucked away in Salem, this expansive 5-bedroom home is a perfect mix of comfort and convenience. Each bedroom features a plush king bed, ensuring a restful stay for every guest. With 7 bathrooms, no one has to wait their turn—perfect for larger groups or families. Thoughtful amenities like WiFi, AC, heating, a washing machine, and an ironmake your stay effortless, while a bathtub and hair dryer add a touch of luxury. Whether you’re in town for a lake getaway or a peaceful escape, this home provides the space and relaxation you need to make unforgettable memories in Salem.

• Bedrooms: 6
• Bathrooms: 6
• Sleeps: 16
• Average Price per Night: $1,602

This stunning 6-bedroom lakefront home, built in 2022, is designed for the ultimate Lake Keowee getaway. With breathtaking sunrise and moonrise views from three oversized porches, every moment here feels magical. Inside, enjoy two full kitchens, a wet bar, a movie theater, and two spacious living rooms, while outside, a fire pit for 16, a gourmet outdoor kitchen, and direct lake access create the perfect setting for relaxation and fun. Paddleboards, a junior kayak, and a game table add to the adventure, and with a marina just a minute away, boat rentals are effortless. Whether you’re exploring hiking trails, state parks, or nearby Clemson University, or simply unwinding by the water, this property has everything for an unforgettable escape. Your private lakeside paradise awaits!

• Bedrooms: 6
• Bathrooms: 6.5
• Sleeps: 12
• Average Price per Night: $1,536

Tucked within a private community, this stunning 6,000 sq. ft. lakefront home is designed for those who appreciate space, comfort, and breathtaking views. Vaulted ceilings, exposed beams, and a grand Great Room with a gas fireplacecreate an inviting atmosphere, while floor-to-ceiling windows and sliding glass doors bring Lake Keowee’s beauty right to you. With six king bedroom suites, multiple living spaces, a wine tasting room, and even a private sauna, this home is ideal for groups looking to relax in style. Step outside and take in the serene surroundings or gather in one of the many indoor spaces designed for connection and comfort. Whether you’re enjoying a lakeside getaway, hosting a wine night, or unwinding in the sauna, this retreat is tailor-made for unforgettable moments on Lake Keowee.

• Bedrooms: 6
• Bathrooms: 4
• Sleeps: 15
• Average Price per Night: $1,500

Nestled in a private gated community, this luxurious lakefront retreat offers breathtaking 180° views, two full-size boat docks, and endless amenities for an unforgettable stay. With 300+ feet of private waterfront, a spacious landscaped backyard, and a lakeside fire pit, relaxation comes naturally. Inside, enjoy modern comforts like an infrared sauna, a workout area, and an 85″ TV, while outside, explore the lake with two kayaks and paddleboards. The secluded setting, surrounded by protected land and uninhabited islands, creates a peaceful oasis, yet restaurants, shops, and Clemson University are just a short drive away. Plus, with solar power providing nearly 100% of the home’s electricity, this eco-friendly retreat is as sustainable as it is beautiful. Whether you’re boating, relaxing by the fire, or paddling through the cove, this Lake Keowee gem is the perfect mix of adventure and tranquility.

• Bedrooms: 5
• Bathrooms: 4.5
• Sleeps: 12
• Average Price per Night: $1,350

This stunningly renovated lakefront estate on North Lake Keowee is the ultimate retreat for families and groups. With breathtaking views from every room, this 5-bedroom, 4.5-bath home offers three king suite master bedrooms, plus a bunk room and additional sleeping space for up to 12 guests. The spacious open floor plan and multiple outdoor decksmake it perfect for gathering, whether you’re sipping cocktails at sunset, relaxing in a rocking chair, or dining lakeside. Adventure awaits with a private dock, kayaks, paddleboards, and jet ski rentals nearby. After a day on the water, unwind in the brand-new hot tub, challenge friends to ping pong and air hockey, or gather around the fire pit and pizza oven. Just 15 minutes from Clemson University and close to hiking, shopping, and more, this Lake Keowee retreat is the perfect blend of relaxation and adventure.

• Bedrooms: 6
• Bathrooms: 5
• Sleeps: 14
• Average Price per Night: $1,275

Situated in the exclusive Cove Harbor community, this luxurious lakefront home is designed for relaxation and adventure. Thoughtfully crafted with comfort in mind, the home offers stunning water views, modern amenities, and seamless access to Lake Keowee. Whether you’re spending your days out on the water, unwinding on the patio, or gathering with family and friends, this retreat provides the perfect setting. Located in a private, gated neighborhood, it’s an ideal escape for those seeking both tranquility and easy access to nearby attractions.

• Bedrooms: 5
• Bathrooms: 4.5
• Sleeps: 10
• Average Price per Night: $1,250

This custom-built lakefront home, tucked away in a quiet cove on the north side of Lake Keowee, offers the perfect escape for families and groups looking to enjoy the best of lake life. Spend your days kayaking, paddleboarding, canoeing, floating on a Lilli Pad, or fishing—all included with your stay. With a private dock in 17 feet of water, bring your own boat or rent one to explore Lake Keowee’s 300 miles of shoreline, waterfalls, and sandy beaches. After a day on the water, soak in the hot tub, relax by the firepit under the stars, or grill on the covered porches. Inside, this 4,400 sq. ft. home features an open floor plan with vaulted ceilings, a gourmet kitchen, a game room with a pool table, and a kitchenette. Conveniently located near hiking trails, golf, and dining, this Lake Keowee retreat has everything you need for an unforgettable getaway.

• Bedrooms: 5
• Bathrooms: 5
• Sleeps: 16
• Average Price per Night: $1,215

Perched on the mountainous north end of Lake Keowee, this brand-new (2023) lakefront retreat offers breathtaking water views from nearly every room. With a private covered boat dock in a gated community, it’s the perfect escape for boaters and lake lovers alike. Designed for both relaxation and entertainment, the home features five bedrooms, each with its own en-suite heated-tile bathroom and lake view, plus vaulted ceilings, a stone gas fireplace, and a gourmet kitchen with a Thor range and double ovens. Unwind in the 9-person hot tub, rinse off in the outdoor tiki shower, or challenge friends to a game in the rec room with a bar and 8-ft slate pool table. End the day by gathering around the outdoor fire pit or exploring the community’s shared grill and firepit area. For a luxurious, lakefront getaway with top-tier amenities, this home is truly unbeatable.

• Bedrooms: 6
• Bathrooms: 5.5
• Sleeps: 21
• Average Price per Night: $1,200

This newly built lakefront home offers direct water views from every room and plenty of activities for a fun and relaxing stay. With kayaks, paddleboards, a shuffleboard table, air hockey, and a TEQ table, there’s something for everyone to enjoy. Inside, the fully stocked kitchen makes meal prep easy, while the game room and board games offer entertainment after a day on the lake. A hot tub provides a place to unwind, and comfortable mattresses ensure a good night’s sleep. Whether you’re looking to explore the water or relax with family and friends, this Lake Keowee retreat is a great spot to settle in and enjoy the lake.