If you’re dreaming of a luxurious beachfront escape, Isle of Palms delivers in spades. Known for its pristine beaches and upscale vibes, this South Carolina gem is home to some of the most opulent vacation rentals in the Lowcountry. From private oceanfront estates with infinity pools to chic modern homes with rooftop decks and gourmet kitchens, these rentals redefine coastal living. Whether you’re planning a family gathering, celebrating in style, or just indulging in a well-deserved retreat, these top-tier properties promise an unforgettable stay. Please note: Clicking on the links will direct you to VRBO, and we may earn a commission if you book through these links.

• Bedrooms: 6
• Bathrooms: 6.5
• Sleeps: 12
• Average Price per Night: $21,000

Tucked under a canopy of live oaks, Peaceful Easy Feeling offers the ultimate beachfront escape on Isle of Palms. This 4,680 sq. ft. home features six bedrooms, six and a half baths, a private pool with a hot tub, and a rooftop deck perfect for sunrise and sunset views. The private boardwalk ensures effortless access to the pristine beach, while the outdoor volleyball court and custom kitchen make it ideal for family gatherings or group retreats. Luxury and relaxation await in this stunning oceanfront retreat!

• Bedrooms: 6
• Bathrooms: 4
• Sleeps: 14
• Average Price per Night: $18,000

Nestled along the prestigious Ocean Blvd., Seascapes offers a perfect blend of charm and convenience for your next beach escape. This six-bedroom, four-bathroom home features multiple oceanfront porches, a private pool, and direct beach access, making it ideal for families or groups. Its prime location puts you just steps from the sand and a short walk to Isle of Palms’ vibrant dining and shopping scene. With stunning ocean views and modern updates, including beautifully renovated bathrooms, this home promises a memorable coastal retreat.

• Bedrooms: 10
• Bathrooms: 10.5
• Sleeps: 28
• Average Price per Night: $8,016

Step into unparalleled beachfront elegance at Belle Mer, an exquisite 10-bedroom, 10.5-bathroom estate on Isle of Palms. Designed with luxury in mind, this stunning home boasts an infinity-edge pool, hot tub, outdoor kitchen, private boardwalk with a gazebo, and five spacious decks perfect for soaking in the breathtaking Atlantic views. Newly renovated with a state-of-the-art kitchen, Brazilian cherry hardwood floors, and carefully crafted spaces, it’s ideal for family reunions, retreats, or upscale gatherings. Experience beachfront living like never before at Belle Mer.

• Bedrooms: 5
• Bathrooms: 4 Full & 2 Half
• Sleeps: 12
• Average Price per Night: $5,500

Welcome to 3900 Palm Blvd, a stunning five-bedroom oceanfront retreat on Isle of Palms. Designed for ultimate relaxation, this luxurious home boasts panoramic ocean views, a private pool and hot tub, and direct beach access via a private boardwalk. Inside, you’ll find elegant living spaces, a grand master suite with a soaking tub, and three additional king bedrooms with ocean-facing porches. A gourmet prep kitchen and spacious dining areas make entertaining a breeze. With its prime location and sophisticated design, this is the perfect getaway for families or groups.

• Bedrooms: 6
• Bathrooms: 8.5
• Sleeps: 12
• Average Price per Night: $4,946

For an unforgettable oceanfront retreat, Piper Point offers a blend of luxury and comfort like no other. This stunning estate features six bedrooms, seven and a half baths, and outdoor spaces designed to impress, including a private pool with a Baja shelf, a hot tub, and a rooftop deck with sweeping views of the Atlantic. Inside, enjoy beautifully curated interiors with spacious living areas and gourmet kitchen amenities. Private beach access and close proximity to Isle of Palms attractions complete the perfect coastal escape.

• Bedrooms: 6
• Bathrooms: 6 Full & 4 Half
• Sleeps: 12
• Average Price per Night: $4,872

Welcome to Modern Tides, a breathtaking six-bedroom retreat on Isle of Palms that redefines luxury living. With stunning ocean views, a private pool, fitness room, game room, and three oceanfront bedrooms, this newly built estate offers the ultimate coastal escape. Thoughtfully designed with high-end finishes and spacious layouts, it’s perfect for families or groups looking to relax in style. Enjoy the convenience of private beach access, multiple porches for taking in the views, and luxurious amenities that make every stay unforgettable.

• Bedrooms: 6
• Bathrooms: 5.5
• Sleeps: 12
• Average Price per Night: $4,620

Step into Serenity, a beautifully renovated oceanfront estate on Isle of Palms. Spanning 8,100 sq. ft., this six-bedroom, 5.5-bathroom retreat offers sweeping ocean views, a private pool and hot tub, and multiple outdoor living spaces, including an outdoor bar and kitchen. Perfect for gatherings, it features three living rooms and a billiards room, blending style and relaxation effortlessly. With direct beach access and an exquisite design, Serenity promises an unparalleled experience for those seeking the ultimate beachfront getaway.

• Bedrooms: 7
• Bathrooms: 7
• Sleeps: 17
• Average Price per Night: $3,672

Experience the epitome of beachfront elegance at Barbados, a beautifully renovated oceanfront retreat on Isle of Palms. With 7 bedrooms and 7 bathrooms spread over 4,100 square feet, this luxurious home accommodates up to 17 guests in style. Features include a custom-designed 50′ zero-entry pool, lush green yard, gourmet kitchen with marble countertops, and sleek modern furnishings. Enjoy direct beach access via a private boardwalk, multiple ocean-facing porches, and an elevator for added convenience. Perfect for a relaxing and upscale coastal getaway.

• Bedrooms: 7
• Bathrooms: 9
• Sleeps: 12
• Average Price per Night: $3,450

For those seeking the pinnacle of beachfront luxury, Sunsational delivers an experience like no other. This newly built 7,000 sq. ft. home features seven spacious bedrooms, each with its own en suite bath, making it ideal for large groups or family gatherings. Highlights include a private pool, hot tub, rooftop deck, yoga room, and even a pickleball court. With private beach access and stunning ocean views from nearly every room, this property sets the stage for an unforgettable coastal retreat.

• Bedrooms: 11
• Bathrooms: 11.5
• Sleeps: 28
• Average Price per Night: $3,440

If you’re dreaming of the ultimate oceanfront escape, Port of Call on Isle of Palms is where luxury and relaxation collide. This incredible 7,000-square-foot home offers everything you could imagine for a perfect getaway. From its private pool and fire pit to its direct boardwalk access to the beach, every detail is designed for comfort and elegance. And the views? Absolutely breathtaking! With space for up to 28 guests, it’s perfect for family reunions or big retreats. The putting green and outdoor decks add a fun, relaxing touch to this unforgettable stay.